Methyl propiolate → HCID 22258265, compound

HRID 1610876Notes

Reaction equation

HRID 1610876 reaction equation
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([C:9](=[O:20])[CH2:10][C:11]2[NH:15][C:14]3[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[N:12]=2)[CH:6]=[CH:7][CH:8]=1.C[O-].[Na+].[C:24](OC)(=[O:27])[C:25]#[CH:26]>>[CH3:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[C:9]([C:10]1[CH:26]=[CH:25][C:24](=[O:27])[N:15]2[C:14]3[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[NH:12][C:11]=12)=[O:20]

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258177HCID 22258177, compound

Product 1

HCID 22258265HCID 22258265, compound

Procedure

The compound is prepared as described in example 25 with 200 mg (0.63 mmol) of 1-(3-Methylphenyl)-2(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone hydrochloride (example XXXXVIII, 68.4 mg (1.27 mmol) of sodium methylate and 53.2 mg (0.63 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-e96ece0aeadf415694d58c9312fe227e
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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