Methyl propiolate → HCID 22258197, compound

HRID 1610877Notes

Reaction equation

HRID 1610877 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:20])[CH2:10][C:11]1[NH:15][C:14]2[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=2[N:12]=1.C[O-].[Na+].[C:24](OC)(=[O:27])[C:25]#[CH:26]>>[F:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:10]1[CH:26]=[CH:25][C:24](=[O:27])[N:15]2[C:14]3[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[NH:12][C:11]=12)=[O:20]

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258205HCID 22258205, compound

Product 1

HCID 22258197HCID 22258197, compound

Procedure

The compound is prepared as described in example 20 with 200 mg (0.54 mmol) of 1-(2-Fluorophenyl)-2-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone hydrochloride (example XXXXVII, 58.6 mg (1.08 mmol) of sodium methylate and 45.6 mg (0.54 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-5e8e54bec3284320add91cecf2e86b63
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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