Methyl propiolate → HCID 22258191, compound

HRID 1610878Notes

Reaction equation

HRID 1610878 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:9](=[O:18])[CH2:10][C:11]2[NH:12][C:13]([CH3:17])=[C:14]([CH3:16])[N:15]=2)[CH:6]=[CH:7][CH:8]=1.C[O-].[Na+].[C:22](OC)(=[O:25])[C:23]#[CH:24]>>[Cl:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[C:9]([C:10]1[CH:24]=[CH:23][C:22](=[O:25])[N:15]2[C:14]([CH3:16])=[C:13]([CH3:17])[NH:12][C:11]=12)=[O:18]

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258228HCID 22258228, compound

Product 1

HCID 22258191HCID 22258191, compound

Procedure

The compound is prepared as described in example 20 with 200 mg (0.70 mmol) of 1-(3-Chlorophenyl)-2-(4,5-dimethyl-1H-imidazol-2-yl)ethanone hydrochloride (example XXV), 65 mg (1.20 mmol) of sodium methylate and 59 mg (0.70 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-7ffecd6a195142b290b6bb7aca983aa5
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

Loading…