Methyl propiolate → HCID 22258210, compound

HRID 1610881Notes

Reaction equation

HRID 1610881 reaction equation
[NH:1]1[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:4]=2[N:3]=[C:2]1[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=1)=[O:12].C[O-].[Na+].[C:26](OC)(=[O:29])[C:27]#[CH:28]>>[F:22][C:19]([F:20])([F:21])[C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=1)[C:11]([C:10]1[CH:28]=[CH:27][C:26](=[O:29])[N:1]2[C:5]3[CH2:6][CH2:7][CH2:8][CH2:9][C:4]=3[NH:3][C:2]=12)=[O:12]

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258255HCID 22258255, compound

Product 1

HCID 22258210HCID 22258210, compound

Procedure

The compound is prepared as described in example 25 with 500 mg (1.62 mmol) of 2-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethanone (example LII), 175 mg (3.25 mmol) of sodium methylate and 136 mg (1.62 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-dc66725abf1b461bb14c111c68987d8c
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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