Propiolic Acid → HCID 22258184, compound

Participants

Reaction Steps

The compound is prepared as described in example 11 with 138 mg (1.97 mmol) of propiolic acid, 383.6 mg (2.37 mmol) of 1-(1H-imidazol-1-ylcarbonyl)-1H-imidazole and 382 mg (1.31 mmol) of 1-(2,4-difluorophenyl)-2-(5-methyl-4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone (example LIV). The isomers are isolated after purification over preparative HPLC (Daicel Chiralpak AD, eluent: iso-hexane-ethanol v/v 60:40):

Provenance & Evidence