HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoquinoline → 1341688-75-2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoquinoline | HCID 8405 | — |
| Reactant | 2,2,2-Trifluoro-N-(hydroxymethyl)acetamide | HCID 3084931 | — |
| Product | 1341688-75-2 | HCID 22258322 | — |
Reaction Steps
Isoquinoline is reacted with N-(hydroxymethyl)trifluoroacetamide in acid followed by reduction to afford isoquinolin-5-yl-methylamine. Carbamylation using aminotetralin as described above, produces aminotetralin-derived ureas in which L═CH2 (methylene) (Scheme 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06984647B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-e816f2eb7b9d4d6997bcd8579dd52141 |
| Source note | uspto-grants-2006_01 |