1,3-Dibromopropane → HCID 23590910, compound

Participants

Reaction Steps

3-(4-Hydroxyphenyl)-2-methyl-2-phenoxypropionic acid ethyl ester (4.0 g, 13.3 mmol) and 1,3-dibromopropane (7.0 mL, 66.6 mmol) are dissolved in methyl ethyl ketone (100 mL). Powdered K2CO3 (2.4 g, 17.3 mmol) is added. The mixture is heated under reflux for 4 h, cooled, filtered and concentrated to an oil. The crude oil is chromatographed (silica gel; hexane/EtOAc, 5:1 to 1:4) to afford the title compound (5.0 g, 89%). MS (ESI) m/z 421 (M+H)+. Step 2.

Provenance & Evidence