HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-[(E)-2-(2,4-difluorophenyl)ethenyl]-4-[[4-[4-[2-[2-(methylsulfanyl)ethyl]-1H-imidazol-1-yl]butyl]phenoxy]methyl]-1,3-oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (E)-4-chloromethyl-2-[2-(2,4-difluorophenyl)ethenyl]oxazole | HCID 12109498 | — |
| Reactant | 4-[4-[2-[2-(methylsulfanyl)ethyl]-1H-imidazol-1-yl]butyl]phenol | HCID 22259315 | — |
| Product | 2-[(E)-2-(2,4-difluorophenyl)ethenyl]-4-[[4-[4-[2-[2-(methylsulfanyl)ethyl]-1H-imidazol-1-yl]butyl]phenoxy]methyl]-1,3-oxazole | HCID 22259344 | 92.6% |
Reaction Steps
Using 4-[4-[4-[2-[2-(methylsulfanyl)ethyl]-1H-imidazol-1-yl]butyl]phenol (500 mg), 65% sodium hydride (69.8 mg) and 4-chloromethyl-2-[(E)-2-(2,4-difluorophenyl)ethenyl]-1,3-oxazole (483 mg), the same reaction as Example 11-(i) was carried out to yield the titled compound (812 mg) as a colorless amorphous form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06984653B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-7eda427bc4c44570995a7074bf58311e |
| Source note | uspto-grants-2006_01 |