HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-[(E)-2-(2,4-difluorophenyl)ethenyl]-4-[[4-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenoxy]methyl]-1,3-oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (E)-4-chloromethyl-2-[2-(2,4-difluorophenyl)ethenyl]oxazole | HCID 12109498 | — |
| Reactant | 4-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol | HCID 22259297 | — |
| Product | 2-[(E)-2-(2,4-difluorophenyl)ethenyl]-4-[[4-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenoxy]methyl]-1,3-oxazole | HCID 22259312 | 55.5% |
Reaction Steps
Using 4-(chloromethyl)-2-[(E)-2-(2,4-difluorophenyl)ethenyl]-1,3-oxazole (274 mg), 4-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol (300 mg) and 65% sodium hydride (39.5 mg), the same reaction as Example 11-(i) was carried out to yield the titled compound (285 mg) as a colorless crystal powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06984653B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-97670cdea98346f5bf51b58351b13fdd |
| Source note | uspto-grants-2006_01 |