Hydrochloric Acid → HCID 22259314, compound

Participants

Reaction Steps

Ethyl [[(E)-2-(4-(trifluoromethyl)phenyl)ethenyl]-1,3-oxazol-4-yl]acetate (1.72 g) was added to a suspension of calcium chloride (2.35 g) and sodium borohydride (1.60 g) in THF-ethanol (10 ml- 10 ml) at 0° C., and the mixture was stirred for 1 hr. The reaction mixture was combined with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography (eluent; ethyl acetate:hexane=1:1 to ethyl acetate) to give the titled compound (1.27 g) as a colorless crystal powder.

Provenance & Evidence