HCID 11559939, compound → (2S)-2-[[3'-fluoro-4'-[[(1-methylethyl)amino]carbonyl]-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

HRID 16110Notes

Reaction equation

HRID 16110 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([O:21][C@@H:22]([CH3:26])[C:23]([OH:25])=[O:24])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH:17]([CH3:19])[CH3:18])=[O:15])=[C:10]([F:20])[CH:9]=2)[CH:7]=1.B(C1C=C([C:42]([F:45])([F:44])[F:43])C=CC=1O[C@@H](C)C(O)=O)(O)O>>[F:20][C:10]1[CH:9]=[C:8]([C:6]2[CH:7]=[C:2]([C:42]([F:45])([F:44])[F:43])[CH:3]=[CH:4][C:5]=2[O:21][C@@H:22]([CH3:26])[C:23]([OH:25])=[O:24])[CH:13]=[CH:12][C:11]=1[C:14]([NH:16][CH:17]([CH3:19])[CH3:18])=[O:15]

Participants

3

Reactant 2

HCID 11559939HCID 11559939, compoundHCID 67277101(2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid

Product 1

HCID 11668764(2S)-2-[[3'-fluoro-4'-[[(1-methylethyl)amino]carbonyl]-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

Procedure

The title compound was prepared using the product of example 34 step a) and (2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid [WO2004089885] by the method of example 32 step b).

Sources & evidence

ORD record
ord-4e93548824f9466bac4bbaa5e68fff4a
Source dataset
uspto-grants-2010_06
Patent number
US07737135B2

Reaction notes

Loading…