(Diethylamino)sulfur trifluoride → HCID 22258131, compound

Participants

Reaction Steps

To a stirred solution of Example 1 Part B compound (461 mg, 1.00 mmol) in CH2Cl2 (10 mL) under argon at 0° C. was added a solution of diethylaminosulfur trifluoride [DAST] (265 μL, 2.0 mmol) in CH2Cl2 (5 mL) over 20 min. The reaction mixture was stirred for an additional 45 min, then quenched with saturated sodium bicarbonate solution and extracted twice with CH2Cl2. The extracts were combined, dried (MgSO4) and evaporated. Purification by flash chromatography on silica gel provided the title compound as a light yellow oil, 218 mg (47% yield). LC/MS gave the correct molecular ion [(M+H)+=463] for the desired compound.

Provenance & Evidence