(2-(trifluoromethyl)phenyl)acetic acid → 7-Bromo-1'-(2-(2-(trifluoromethyl)phenyl)acetyl)spiro[isoindoline-1,4'-piperidin]-3-one
Reaction equation
[Br:15][c:16]1[cH:17][cH:18][cH:19][c:20]2[c:24]1[C:23]1([NH:22][C:21]2=[O:30])[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]1.[F:1][C:2]([c:3]1[c:4]([CH2:9][C:10](=[O:11])[OH:12])[cH:5][cH:6][cH:7][cH:8]1)([F:13])[F:14]>>[F:1][C:2]([c:3]1[c:4]([CH2:9][C:10](=[O:12])[N:27]2[CH2:26][CH2:25][C:23]3([NH:22][C:21](=[O:30])[c:20]4[cH:19][cH:18][cH:17][c:16]([Br:15])[c:24]43)[CH2:29][CH2:28]2)[cH:5][cH:6][cH:7][cH:8]1)([F:13])[F:14]Participants
3
Sources & evidence
- ORD record
- ord-ff2a3fa0dd694896be65755c7a3aa807
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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