Sodium borohydride → HCID 22258030, compound

HRID 1611045Notes

Reaction equation

HRID 1611045 reaction equation
[BH4-].[Na+].[NH2:3][C:4]1[S:5][C:6]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:8]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10]>CC(C)C(O)=O>[CH3:6][CH:7]([CH3:14])[CH2:8][NH:3][C:4]1[S:5][C:6]([CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:8]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 22257988HCID 22257988, compound

Product 1

HCID 22258030HCID 22258030, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 6590Isobutyric AcidSolvent

Procedure

Prepared from sodium borohydride (2.2 g) and diethyl 2-amino-5-phenylmethylthiophene-3,4-dicarboxylate (4.10 g) in 2-methylpropanoic acid (20 ml) following the method of Example 3 step b to give the subtitle compound (2.39 g) as an oil.

Sources & evidence

ORD record
ord-9bf7d895617d4e1680d7d6f9fcddc8d3
Source dataset
uspto-grants-2006_01
Patent number
US06984644B2

Reaction notes

Loading…