反应详情

300 mg of 2-(n-butyl)-5-nitro-2,3-dihydrobenzofuran-3-ol were introduced into ethanol in a 50 ml flask, and 1 ml of concentrated sulphuric acid was added. The mixture was then heated to reflux for 4 hours. After cooling, 10 ml of water were added, the ethanol was distilled off, and the mixture was extracted with dichloromethane. Washing of the organic phase with sodium bicarbonate solution, drying over sodium sulphate and removal of the solvent in vacuo resulted in 220 mg (80% of theory) of 2-(n-butyl)-5-nitrobenzofuran as yellow oil.

1. temperatureThe mixture was then heated
2. temperatureto reflux for 4 hours
3. temperatureAfter cooling
4. distillationthe ethanol was distilled off
5. extractionthe mixture was extracted with dichloromethane
6. washWashing of the organic phase with sodium bicarbonate solution
7. dry with materialdrying over sodium sulphate and removal of the solvent in vacuo
8. customresulted in 220 mg (80% of theory) of 2-(n-butyl)-5-nitrobenzofuran as yellow oil