(4-Cyanophenyl)methanesulfonyl chloride → HCID 10218983, compound

HRID 1611110Notes

Reaction equation

HRID 1611110 reaction equation
C[O:2][C:3](=[O:39])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][C:13]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([Cl:22])[CH:20]=3)[N:15]([CH:23]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:14]=2[CH2:36][CH2:37][NH2:38])=[CH:6][CH:5]=1.[C:40]([C:42]1[CH:47]=[CH:46][C:45]([CH2:48][S:49](Cl)(=[O:51])=[O:50])=[CH:44][CH:43]=1)#[N:41]>>[CH:23]([N:15]1[C:16]2[C:21](=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[C:13]([CH2:12][CH2:11][O:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:2])=[O:39])=[CH:5][CH:6]=2)=[C:14]1[CH2:36][CH2:37][NH:38][S:49]([CH2:48][C:45]1[CH:46]=[CH:47][C:42]([C:40]#[N:41])=[CH:43][CH:44]=1)(=[O:51])=[O:50])([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 15480555(4-Cyanophenyl)methanesulfonyl chlorideHCID 16116212HCID 16116212, compound

Product 1

HCID 10218983HCID 10218983, compound

Procedure

The title compound was prepared from 4-{2-[2-(2-amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethoxy}-benzoic acid methyl ester (Step 6, Example 1)and (4-cyano-phenyl)-methanesulfonyl chloride according to Example 1 Step 7.

Sources & evidence

ORD record
ord-8e2136599a134eba90d8cd526510cdb4
Source dataset
uspto-grants-2006_01
Patent number
US06984735B2

Reaction notes

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