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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611263Generated: October 26, 2026

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione → 1-(Cyclobutylmethyl)-6-(3,5-dimethylphenoxy)-5-ethyl-pyrimidine-2,4-dione

https://huagongshe.com/reaction/1611263

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 10923266—
ReactantCyclobutylmethyl 4-methylbenzenesulfonateHCID 13163931—
Product1-(Cyclobutylmethyl)-6-(3,5-dimethylphenoxy)-5-ethyl-pyrimidine-2,4-dioneHCID 994934258.5%

Reaction Steps

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and (cyclobutyl)methyl para-toluenesulfonate were reacted by the same way with the example 1 to obtain the titled compound (192 mg, yield: 58.5%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-9db64a969c444453be515a0d74a73ce1
Source noteuspto-grants-2006_01