Cyclobutylmethyl 4-methylbenzenesulfonate → 1-(Cyclobutyl)methyl-5-isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

HRID 1611264Notes

Reaction equation

HRID 1611264 reaction equation
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[O:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].C1(C)C=CC(S(O[CH2:31][CH:32]2[CH2:35][CH2:34][CH2:33]2)(=O)=O)=CC=1>>[CH:32]1([CH2:31][N:8]2[C:9]([O:10][C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]2=[O:19])[CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 13163931Cyclobutylmethyl 4-methylbenzenesulfonateHCID 222565785-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 159577031-(Cyclobutyl)methyl-5-isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneYield 47.9%

Procedure

5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and (cyclobutyl)methyl para-toluenesulfonate were reacted by the same way with the example 1 to obtain the titled compound (164 mg, yield: 47.9%).

Sources & evidence

ORD record
ord-52517a6f8b7448fdb2d072d3e42fa9d9
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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