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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611286Generated: October 30, 2026

1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 1-(4-Trifluoromethoxybenzyl)-5-isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

https://huagongshe.com/reaction/1611286

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 142785—
Reactant5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 22256578—
Product1-(4-Trifluoromethoxybenzyl)-5-isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 1595771847.3%

Reaction Steps

5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 4-trifluoromethoxybenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (212 mg, yield: 47.3%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-e938fe03f5e64ac48ae3c38ab9a66a5f
Source noteuspto-grants-2006_01