2-(Bromomethyl)benzonitrile → HCID 15957721, compound

HRID 1611289Notes

Reaction equation

HRID 1611289 reaction equation
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[S:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[C:20]([C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24]Br)#[N:21]>>[C:20]([C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24][N:7]1[C:8]([S:9][C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]1=[O:18])#[N:21]

Participants

3

Reactant 2

HCID 895992-(Bromomethyl)benzonitrileHCID 104927276-(3,5-dimethylphenyl)sulfanyl-5-ethyl-1H-pyrimidine-2,4-dione

Product 1

HCID 15957721HCID 15957721, compoundYield 41.3%

Procedure

5-Ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 2-cyanobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (162 mg, yield: 41.3%).

Sources & evidence

ORD record
ord-6e1bf75ea3cd40e2a549cdbec8ece045
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

Loading…