Cyclopropylamine → 4-bromo-N-cyclopropyl-2-fluorobenzamide

HRID 16113Notes

Reaction equation

[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH:12]1([NH2:15])[CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:15][CH:12]2[CH2:14][CH2:13]2)=[O:8])=[C:4]([F:11])[CH:3]=1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 3026814-Bromo-2-fluorobenzoic acid

Product 1

HCID 90800384-bromo-N-cyclopropyl-2-fluorobenzamide

Procedure

The sub-title compound was prepared by the method of example 18 step a) using) 4-bromo-2-fluorobenzoic acid, and cyclopropylamine.

Sources & evidence

ORD record: ord-7121b60fdfa7499ebaa69d71a66da0f6
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07737135B2

Reaction notes

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