3,5-Bis(trifluoromethyl)benzyl bromide → HCID 15957746, compound

HRID 1611316Notes

Reaction equation

HRID 1611316 reaction equation
[CH2:1]([C:3]1[C:4](=[O:20])[NH:5][C:6](=[O:19])[NH:7][C:8]=1[C:9](=[O:18])[C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[F:21][C:22]([F:36])([F:35])[C:23]1[CH:24]=[C:25]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:26]Br>>[F:21][C:22]([F:35])([F:36])[C:23]1[CH:24]=[C:25]([CH:28]=[C:29]([C:31]([F:34])([F:32])[F:33])[CH:30]=1)[CH2:26][N:7]1[C:8]([C:9](=[O:18])[C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:20])[NH:5][C:6]1=[O:19]

Participants

3

Reactant 2

HCID 1225733,5-Bis(trifluoromethyl)benzyl bromideHCID 222565796-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 15957746HCID 15957746, compoundYield 56.2%

Procedure

5-Ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 3,5-bis(trifluoromethyl)benzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (280 mg, yield: 56.2%).

Sources & evidence

ORD record
ord-76ca533323644c3585b71e293a5c4539
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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