3,5-Bis(trifluoromethyl)benzyl bromide → HCID 5280015, compound

HRID 1611317Notes

Reaction equation

HRID 1611317 reaction equation
[CH:1]([C:4]1[C:5](=[O:21])[NH:6][C:7](=[O:20])[NH:8][C:9]=1[C:10](=[O:19])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[F:22][C:23]([F:37])([F:36])[C:24]1[CH:25]=[C:26]([CH:29]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:31]=1)[CH2:27]Br>>[F:22][C:23]([F:36])([F:37])[C:24]1[CH:25]=[C:26]([CH:29]=[C:30]([C:32]([F:35])([F:33])[F:34])[CH:31]=1)[CH2:27][N:8]1[C:9]([C:10](=[O:19])[C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:21])[NH:6][C:7]1=[O:20]

Participants

3

Reactant 2

HCID 1225733,5-Bis(trifluoromethyl)benzyl bromideHCID 222565826-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Product 1

HCID 5280015HCID 5280015, compoundYield 49.8%

Procedure

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 3,5-bis(trifluoromethyl)benzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (255 mg, yield: 49.8%).

Sources & evidence

ORD record
ord-4b1ffc21ebfe420eb39fb891c2ebb912
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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