Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611318Generated: October 27, 2026

2-(Bromomethyl)-1,4-difluorobenzene → 1-(2,5-Difluorobenzyl)-5-ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione

https://huagongshe.com/reaction/1611318

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Bromomethyl)-1,4-difluorobenzeneHCID 522830—
Reactant6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-1H-pyrimidine-2,4-dioneHCID 10492727—
Product1-(2,5-Difluorobenzyl)-5-ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedioneHCID 1595774742.2%

Reaction Steps

5-Ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 2,5-difluorobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (170 mg, yield: 42.2%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-c2cf057691744092b6d16722715d1da3
Source noteuspto-grants-2006_01