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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611319Generated: October 27, 2026

2-(Bromomethyl)-1,4-difluorobenzene → 1-(2,5-Difluorobenzyl)-5-isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione

https://huagongshe.com/reaction/1611319

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Bromomethyl)-1,4-difluorobenzeneHCID 522830—
Reactant5-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedioneHCID 10493727—
Product1-(2,5-Difluorobenzyl)-5-isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedioneHCID 1595774849.2%

Reaction Steps

5-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 2,5-difluorobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (205 mg, yield: 49.2%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-be482586847c469493e26e9e7704e41a
Source noteuspto-grants-2006_01