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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611324Generated: November 2, 2026

3,5-Difluorobenzyl bromide → 1-[(3,5-Difluorophenyl)methyl]-6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-pyrimidine-2,4-dione

https://huagongshe.com/reaction/1611324

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluorobenzyl bromideHCID 518896—
Reactant6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-1H-pyrimidine-2,4-dioneHCID 10492727—
Product1-[(3,5-Difluorophenyl)methyl]-6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-pyrimidine-2,4-dioneHCID 993095648.7%

Reaction Steps

5-Ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 3,5-difluorobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (196 mg, yield: 48.7%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-da5b138581fe4af9850a26d364079a52
Source noteuspto-grants-2006_01