HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Difluorobenzyl bromide → 1-[(3,5-Difluorophenyl)methyl]-6-(3,5-dimethylbenzoyl)-5-isopropyl-pyrimidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Difluorobenzyl bromide | HCID 518896 | — |
| Reactant | 6-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione | HCID 22256582 | — |
| Product | 1-[(3,5-Difluorophenyl)methyl]-6-(3,5-dimethylbenzoyl)-5-isopropyl-pyrimidine-2,4-dione | HCID 5280014 | 53.3% |
Reaction Steps
5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 3,5-difluorobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (220 mg, yield: 53.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06987114B1 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-5314071e3e9e4ec9985da4f9ba04657b |
| Source note | uspto-grants-2006_01 |