1-(Bromomethyl)-3,5-dichlorobenzene → HCID 15957760, compound

HRID 1611334Notes

Reaction equation

HRID 1611334 reaction equation
[CH:1]([C:4]1[C:5](=[O:21])[NH:6][C:7](=[O:20])[NH:8][C:9]=1[C:10](=[O:19])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[Cl:22][C:23]1[CH:24]=[C:25]([CH:28]=[C:29]([Cl:31])[CH:30]=1)[CH2:26]Br>>[Cl:22][C:23]1[CH:24]=[C:25]([CH:28]=[C:29]([Cl:31])[CH:30]=1)[CH2:26][N:8]1[C:9]([C:10](=[O:19])[C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:21])[NH:6][C:7]1=[O:20]

Participants

3

Reactant 2

HCID 125839781-(Bromomethyl)-3,5-dichlorobenzeneHCID 222565826-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Product 1

HCID 15957760HCID 15957760, compoundYield 63.6%

Procedure

5-isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 3,5-dichlorobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (283 mg, yield: 63.6%).

Sources & evidence

ORD record
ord-b5b30cc160434c5c90987b1571810d29
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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