3,5-Dibromobenzyl bromide → 1-(3,5-Dibromobenzyl)-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

HRID 1611337Notes

Reaction equation

HRID 1611337 reaction equation
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[O:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[Br:20][C:21]1[CH:22]=[C:23]([CH:26]=[C:27]([Br:29])[CH:28]=1)[CH2:24]Br>>[Br:20][C:21]1[CH:22]=[C:23]([CH:26]=[C:27]([Br:29])[CH:28]=1)[CH2:24][N:7]1[C:8]([O:9][C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]1=[O:18]

Participants

3

Reactant 2

HCID 1434273,5-Dibromobenzyl bromideHCID 109232665-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 159577631-(3,5-Dibromobenzyl)-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneYield 73.9%

Procedure

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 3,5-dibromobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (375 mg, yield: 73.9%).

Sources & evidence

ORD record
ord-9804d928632c498f81b4710844945c10
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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