2-(Chloromethyl)anthraquinone → 6-(3,5-Dimethylbenzoyl)-1-[(9,10-dioxo-2-anthryl)methyl]-5-isopropyl-pyrimidine-2,4-dione

HRID 1611352Notes

Reaction equation

HRID 1611352 reaction equation
[CH:1]([C:4]1[C:5](=[O:21])[NH:6][C:7](=[O:20])[NH:8][C:9]=1[C:10](=[O:19])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].Cl[CH2:23][C:24]1[CH:37]=[CH:36][C:35]2[C:34](=[O:38])[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:27](=[O:39])[C:26]=2[CH:25]=1>>[CH:25]1[C:26]2[C:27](=[O:39])[C:28]3[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:34](=[O:38])[C:35]=2[CH:36]=[CH:37][C:24]=1[CH2:23][N:8]1[C:9]([C:10](=[O:19])[C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:21])[NH:6][C:7]1=[O:20]

Participants

3

Reactant 2

HCID 3443112-(Chloromethyl)anthraquinoneHCID 222565826-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Product 1

HCID 159577846-(3,5-Dimethylbenzoyl)-1-[(9,10-dioxo-2-anthryl)methyl]-5-isopropyl-pyrimidine-2,4-dioneYield 38%

Procedure

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 2-chloromethyl anthraquinone were reacted by the same way with the example 1 to obtain the titled compound (193 mg, yield: 38.0%).

Sources & evidence

ORD record
ord-20a0715086644a499e299e5f3fee3d9a
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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