Picolyl chloride → 6-(3,5-Dimethylphenyl)sulfanyl-5-ethyl-1-(2-pyridylmethyl)pyrimidine-2,4-dione

HRID 1611353Notes

Reaction equation

[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[S:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26]Cl>>[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][N:7]1[C:8]([S:9][C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]1=[O:18]

Participants

Reactant 2

HCID 23393Picolyl chloride

HCID 104927276-(3,5-dimethylphenyl)sulfanyl-5-ethyl-1H-pyrimidine-2,4-dione

Product 1

HCID 159577856-(3,5-Dimethylphenyl)sulfanyl-5-ethyl-1-(2-pyridylmethyl)pyrimidine-2,4-dioneYield 26.7%

Procedure

5-Ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 2-picolyl chloride were reacted by the same way with the example 1 to obtain the titled compound (98 mg, yield: 26.7%).

Sources & evidence

ORD record: ord-33f1821b23a44c01a4dc3270085378ed
Source dataset: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06987114B1

Reaction notes

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