3-(Chloromethyl)pyridine → HCID 5279973, compound

HRID 1611363Notes

Reaction equation

HRID 1611363 reaction equation
[CH:1]([C:4]1[C:5](=[O:21])[NH:6][C:7](=[O:20])[NH:8][C:9]=1[C:10](=[O:19])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28]Cl)[CH:23]=1>>[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][N:8]2[C:9]([C:10](=[O:19])[C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:21])[NH:6][C:7]2=[O:20])[CH:23]=1

Participants

3

Reactant 2

HCID 183583-(Chloromethyl)pyridineHCID 222565826-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Product 1

HCID 5279973HCID 5279973, compoundYield 40.3%

Procedure

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 3-picolyl chloride were reacted by the same way with the example 1 to obtain the titled compound (152 mg, yield: 40.3%).

Sources & evidence

ORD record
ord-023d75727b724cf3803dc85a2762a3a3
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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