2-(Chloromethyl)quinoline → HCID 15957805, compound

HRID 1611365Notes

Reaction equation

HRID 1611365 reaction equation
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[O:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].Cl[CH2:21][C:22]1[CH:31]=[CH:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:23]=1>>[N:23]1[C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:30]=[CH:31][C:22]=1[CH2:21][N:7]1[C:8]([O:9][C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]1=[O:18]

Participants

3

Reactant 2

HCID 203942-(Chloromethyl)quinolineHCID 109232665-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 15957805HCID 15957805, compoundYield 32.4%

Procedure

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 2-chloromethyl quinoline were reacted by the same way with the example 1 to obtain the titled compound (130 mg, yield: 32.4%).

Sources & evidence

ORD record
ord-5481bac274f94964b236ca4855f8269f
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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