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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611368Generated: October 28, 2026

2-(Chloromethyl)quinoline → 6-(3,5-Dimethylbenzoyl)-5-isopropyl-1-(2-quinolylmethyl)pyrimidine-2,4-dione

https://huagongshe.com/reaction/1611368

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Chloromethyl)quinolineHCID 20394—
Reactant6-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dioneHCID 22256582—
Product6-(3,5-Dimethylbenzoyl)-5-isopropyl-1-(2-quinolylmethyl)pyrimidine-2,4-dioneHCID 1595780839.8%

Reaction Steps

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 2-chloromethyl quinoline were reacted by the same way with the example 1 to obtain the titled compound (170 mg, yield: 39.8%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-2f45f929dbe041b0b8f55676382c7160
Source noteuspto-grants-2006_01