Allyl bromide → HCID 22256583, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione (258 mg, 1.0 mmol) and allyl bromide(121 mg, 1.0 mmol) dissolved in dimethylformamide(5 ml), sodium bicarbonate(126 mg, 1.50 mmol) and lithium iodide(13.0 mg, 0.10 mmol) were added and stirred at 90° C. for 24 hours. The resulting product was distilled under the reduced pressure to remove dimethylformamide and purified by column chromatography to obtain the titled compound as a white solid(157 mg, yield: 52.3%).

Provenance & Evidence