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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611378Generated: November 1, 2026

2-(Chloromethyl)-1,3-benzoxazole → 1-(Benzoxazol-2-ylmethyl)-5-ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione

https://huagongshe.com/reaction/1611378

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Chloromethyl)-1,3-benzoxazoleHCID 2061989—
Reactant6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-1H-pyrimidine-2,4-dioneHCID 10492727—
Product1-(Benzoxazol-2-ylmethyl)-5-ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedioneHCID 995320643.2%

Reaction Steps

5-Ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 2-chloromethyl benzoxazole were reacted by the same way with the example 1 to obtain the titled compound (176 mg, yield: 43.2%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-9c54000e22bc4b4d805ea9c87d3893e1
Source noteuspto-grants-2006_01