2-(Chloromethyl)-1,3-benzoxazole → HCID 15957816, compound

HRID 1611379Notes

Reaction equation

HRID 1611379 reaction equation
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[S:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].Cl[CH2:22][C:23]1[O:24][C:25]2[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=2[N:27]=1>>[O:24]1[C:25]2[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=2[N:27]=[C:23]1[CH2:22][N:8]1[C:9]([S:10][C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]1=[O:19]

Participants

3

Reactant 2

HCID 20619892-(Chloromethyl)-1,3-benzoxazoleHCID 104937275-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione

Product 1

HCID 15957816HCID 15957816, compoundYield 44.8%

Procedure

5-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 2-chloromethyl benzoxazole were reacted by the same way with the example 1 to obtain the titled compound (189 mg, yield: 44.8%).

Sources & evidence

ORD record
ord-2d81b0bc288d4615b1af1c7d23bebbb5
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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