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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611380Generated: October 31, 2026

2-(Chloromethyl)-1,3-benzoxazole → 1-(Benzoxazol-2-ylmethyl)-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

https://huagongshe.com/reaction/1611380

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Chloromethyl)-1,3-benzoxazoleHCID 2061989—
Reactant5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 10923266—
Product1-(Benzoxazol-2-ylmethyl)-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 980062754.9%

Reaction Steps

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 2-chloromethyl benzoxazole were reacted by the same way with the example 1 to obtain the titled compound (215 mg, yield: 54.9%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-764c84305ee642e18145c385611fae7e
Source noteuspto-grants-2006_01