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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611381Generated: November 4, 2026

2-(Chloromethyl)-1,3-benzoxazole → 1-(Benzoxazol-2-ylmethyl)-5-isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

https://huagongshe.com/reaction/1611381

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Chloromethyl)-1,3-benzoxazoleHCID 2061989—
Reactant5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 22256578—
Product1-(Benzoxazol-2-ylmethyl)-5-isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 1595781751.1%

Reaction Steps

5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 2-chloromethyl benzoxazole were reacted by the same way with the example 1 to obtain the titled compound (207 mg, yield: 51.1%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-3f074cc5bcee4fe8bf2b9922ef8d0038
Source noteuspto-grants-2006_01