Methyl 2-(Bromomethyl)-3-Furoate → 1-(3-Methoxycarbonyl-2-furanylmethyl)-5-ethyl-6-(3,5-dimethyl-benzoyl)-2,4-pyrimidinedione

HRID 1611386Notes

Reaction equation

HRID 1611386 reaction equation
[CH2:1]([C:3]1[C:4](=[O:20])[NH:5][C:6](=[O:19])[NH:7][C:8]=1[C:9](=[O:18])[C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].Br[CH2:22][C:23]1[O:24][CH:25]=[CH:26][C:27]=1[C:28]([O:30][CH3:31])=[O:29]>>[CH3:31][O:30][C:28]([C:27]1[CH:26]=[CH:25][O:24][C:23]=1[CH2:22][N:7]1[C:8]([C:9](=[O:18])[C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:20])[NH:5][C:6]1=[O:19])=[O:29]

Participants

3

Reactant 2

HCID 2736827Methyl 2-(Bromomethyl)-3-FuroateHCID 222565796-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 159578231-(3-Methoxycarbonyl-2-furanylmethyl)-5-ethyl-6-(3,5-dimethyl-benzoyl)-2,4-pyrimidinedioneYield 38%

Procedure

5-Ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 2-bromomethyl-3-methoxycarbonylfurane were reacted by the same way with the example 1 to obtain the titled compound (150 mg, yield: 38.0%).

Sources & evidence

ORD record
ord-be0a62c31c39443293ed183de0d9fcc7
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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