Piperidine → HCID 178519951, compound

Participants

Reaction Steps

The product of Step 1 (52 mg, 0.15 mmol) was dissolved in anhydrous dichloromethane (3 ml), piperidine (0.025 ml, 0.23 mmol) was added followed by triethylamine (0.084 ml, 0.6 mmol) and the mixture stirred at room temperature for 2 hours. The mixture was diluted with dichloromethane and washed with aqueous sodium bicarbonate and brine. The organic layer was dried (MgSO4) and evaporated under vacuum. The residue was chromatographed on silica gel eluting with 5% of a 9:1 methanol:0.880 ammonia solution, in dichloromethane to give the title compound as a white solid (16 mg, 26%); MS(AP+) m/e 402 [M+H]+.

Provenance & Evidence