Triethylamine → HCID 178483824, compound

Participants

Reaction Steps

The product from Step 2 (124 mg, 0.3 mmol) was suspended in dichioromethane (5 ml) and treated with a solution of N,N-dimethyl ethylenediamine (0.036 ml, 0.33 mmol), and triethylamine (0.125 ml, 0.9 mmol) in dichloromethane (1 ml). The reaction mixture was then stirred at room temperature overnight, washed saturated sodium bicarbonate solution (3 ml) and passed through a Varain Chem Elut hydromatric cartridge to remove the aqueous phase. The filtrate was then concentrated and purified by silica gel chromatography, eluting with 0.3:3:7 dichloromethane: ethanol:0.880 ammonia solution to afford the title compound (20 mg, 17%); MS(AP+) m/e 386/388 [M+H]+

Provenance & Evidence