Tetrahydrofuran → HCID 178520232, compound

Participants

Reaction Steps

To a solution of [2-[(2,6-dichlorophenyl)amino]benzeneacetyloxy](L)-histidine (5 g, 11,54 mmoles) in tetrahydrofuran (100 ml) triphenylphosphine (9.08 g, 34.62 mmoles) and carbon tetrabromide (11.48 g, 34.62 mmoles) are added under stirring. The reaction mixture is left at room temperature for 24 hours, then the solvent is removed by evaporation at reduced pressure. The obtained crude product is purified by chromatography on silica gel eluting with n-hexane/ethyl acetate 1/1. (S)-[2-[(2,6-dichlorophenyl)amino]benzeneacetyloxy](L)-histidine 4-bromobutyl ester is obtained.

Provenance & Evidence