HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611412Generated: November 3, 2026
Potassium Carbonate → 2-(Isoquinolin-7-yloxy)-2-methyl-propionic acid ethyl ester
https://huagongshe.com/reaction/1611412
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Propanoic acid, 2-bromo-2-methyl-, ethyl ester | HCID 11745 | — |
| Reactant | 7-Isoquinolinol | HCID 459767 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(Isoquinolin-7-yloxy)-2-methyl-propionic acid ethyl ester | HCID 23591466 | 53.3% |
Reaction Steps
7-Hydroxyisoquinoline (500 mg, 3.4 mmol), ethyl 2-bromoisobutyrate (3 g, 15 mmol) and potassium carbonate (2.1 g, 15 mmol) were mixed in 7 ml of anhydrous DMF. The reaction was heated to 95° C. under N2 for 18 hrs. The reaction was concentrated under reduced pressure and purified by flash column chromatography (33% EtOAc/Hexanes) to yield 470 mg (53%) of the title product of this preparation as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06987118B2 |
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| Source dataset | uspto-grants-2006_01 |
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| ORD ID | ord-9ea8ce77ec37472da4ba10728e4e34ff |
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| Source note | uspto-grants-2006_01 |
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