Trifluoroacetic acid → HCID 131725258, compound

Participants

Reaction Conditions

Reaction Steps

The octapeptide ester XVIII (11 g, 7.9 mm anisole, 2 ml) and mercaptoethanol (2 ml) are suspended in DCM (20 ml) under N2. The suspension is cooled to 0° C. and TFA (80 ml) is added. Stirring is continued for one and half hour at same temperature. The TFA and DCM are evaporated under vacuum at 30° C., ether (200 ml) is added to the residue under stirring. The precipitates are filtered, washed with diethyl ether (300 ml) and dried in vacuum to give compound XIX: Yield 10.0 g (91%). ESMS=1191 (M+H). H-(D)-Phe-Cys(Acm)-Phe-(D)-Trp-Lys-Thr-Cys(Acm)-Throninol·2TFA  (XVI)

Provenance & Evidence