N-Iodosuccinimide → HCID 10984692, compound

Participants

Reaction Steps

Compound (46) is prepared as described for compound (45) by proceeding from compound (18) (500 mg, 1.11 mmol) and N-iodosuccinimide (264 mg, 1.16 mmol). The duration of the reaction is 23 h. Colorless crystals (590 mg, 92%) are obtained from cyclohexane. 1H-NMR ([D6] DMSO): δ=1.9 (d, J=7.0, CH3), 1.15 (d, J=7.0, CH3), 2.46, 2.60, 2.89 (3 m, CH and Hα,β-C(2′)), 4.06 (s, OCH3), 4.17 (m, H—C(5′)), 4.27 (m, H—C(4′)), 5.35 (m, H—C(3′)), 6.46 (m, H—C(1′)), 7.62 (s, H—C(6)), 9.55 (d, J=9.7, NH), 10.81 (d, J=9.9 HCO). Anal. calculated for C21H27JN4O7 (574.4): C 43.91, H 4.74, N 9.75; found: C 43.98, H 4.75, N 9.82.

Provenance & Evidence