2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester → HCID 69235551, compound

Participants

Reaction Steps

A mixture of 5-phenyl-3-thienylamine (1.00 g, 5.7 mmol) and ethyl (ethoxymethylene)cyanoacetate (950 mg, 5.7 mmol) in 20 mL of toluene is heated at reflux for 45 minutes. The reaction mixture is filtered while warm and the collected solid is washed with diethyl ether to provide 198 mg of ethyl 2-cyano-3-[(5-phenyl-3-thienyl)amino]-2-propenoate as white crystals, mp 190-193° C.; MS 296.9 (M−H)−.

Provenance & Evidence