Hydrazine hydrate (1:1) → HCID 11047052, compound

Participants

Reaction Steps

To a solution of compound 4a (40 mg, 0.1 mmol) in ethanol (10 mL), Ra—Ni (˜50 mg) then hydrazine hydrate (0.2 mL) were added and the reaction stirred at room temperature for 3 h. The catalyst was filtered through the Celite and filtrate was concentrated in vacuo to provide 26 mg of a solid (69.1% yield); mp 245–246° C.; 1H NMR (CDCl3) δ 2.36 (s, 6H), 3.01 (t, 2H, J=7.4), 4.11(s, 2H), 4.68 (t, 2H, J=7.4), 6.17(s, 2H,), 7.18 (dd, 1H, J=2.8, 11.4), 7.46 (s, 1H) 7.71 (d, 1H, J=3), 7.80 (s, 1H) 8.20 (d, 1H, J=8.8), 9.40 (s, 1H); HRMS m/z calcd for C21H20N4O3H: 377.1614. found 377.1604.

Provenance & Evidence