Hydrazine hydrate (1:1) → HCID 11025207, compound

Participants

Reaction Steps

To a solution of compound 6a (40 mg, 0.1 mmol) in ethanol (10 mL), Ra—Ni (˜50 mg) and then hydrazine hydrate (0.2 mL) were added and reaction was stirred at room temperature for 3 h. The catalyst was filtered through the Celite and filtrate was concentrated in vacuo to provide 28 mg of a solid (74.4% yield); mp 223–224° C.; 1H NMR (CDCl3) δ 2.31 (s, 6H), 2.90 (t, 2H, J=7), 4.34 (s, 2H), 4.65 (t, 2H, J=7.4), 6.18 (s, 2H,), 7.16 (d, 1H, J=8), 7.4 (dd, 2H, J=7.6, 9.8) 7.74 (s, 1H), 8.02 (d, 1H, J=7.8), 10.03 (s, 1H); HRMS m/z calcd for C21H20N4O3H: 377.1614. found 377.1631.

Provenance & Evidence