S-(2-Aminoethyl) ethanethioate--hydrogen chloride (1/1) → HCID 516560, compound

Participants

Reaction Steps

The coupling reaction of 7 (4.5 mmol) with S-isobutyrylcysteamine hydrochloride [(compound obtained according to the same methods as those described by T. Wieland and E. Bokelman, Ann. Chem., 1952, 576; 20-34; during the syntheses of S-acetylcysteamine hydrochloride and S-benzoylcysteamine hydrochloride) M.p.=147-148° C.] is carried out according to method B described in the first synthetic route (example 1). After the various treatments, the expected compound is isolated by flash chromatography on a silica gel column (eluent: CH2Cl2/ether 30%). 10 is collected in the form of a colorless foam with a yield of 80%. Rf (AcOEt/petroleum ether, 8/2): 0.37. [α]D20=+10° (c 1.1, CHCl3).

Provenance & Evidence